NootBro's Daily Regimen (March 2023)
Every supplement, nootropic, & drug I'm currently taking daily
Since everyone is asking…
I'm about to let you in on my daily protocol of supplements, nootropics, and drugs. This stack is designed for performance & longevity to keep me at the top of my game both today & in 30 years.
This protocol will be split into 4 parts: general health supplements, testosterone boosters & aphrodisiacs, nootropics, & drugs. This reflects what I consistently take daily. This does not include as-needed agents or other compounds I’m experimenting with.
Let’s get started…
MEDICAL DISCLAIMER
The NootBro newsletter does not contain medical advice. I am NOT a doctor. The contents of this newsletter, such as videos, text, graphics, external links, images, and other material are intended for entertainment, informational and educational purposes only and not to render medical advice. The contents of this newsletter are not intended to substitute for professional medical advice, diagnosis, or treatment. Although I make efforts to keep the medical information in this newsletter current, I cannot guarantee that the information in this newsletter or on my social media channels reflects the most up-to-date research.
Consult your physician for medical advice. Always seek the advice of a physician or other qualified healthcare provider with any questions regarding a medical condition. Never disregard or delay seeking professional medical advice or treatment because of something you have heard on the Internet. Before taking any medications, over-the-counter drugs, supplements, or herbs, consult a physician for a thorough evaluation. This channel does not endorse any medications, vitamins, or herbs nor do we condone the use of illegal drugs or using drugs for an unintended purpose. A qualified physician should make a decision based on each person's medical history and current prescriptions.
General Health Supplements
#1 - N-Acetyl Cysteine (NAC)
N-Acetyl Cysteine, or NAC, is a potent antioxidant & glutathione precursor that helps to increase the levels of glutathione in the body. I take NAC for the antioxidant benefits, liver protection, & brain benefits. NAC is also especially helpful for psychiatric disorders such as OCD (Source), which I used to struggle with. I typically take 1200mg per day of Nootropics Depot’s NAC.
#2 - TUDCA
TUDCA, or Tauroursodeoxycholic acid, is a bile acid that can be naturally found in the body. I take TUDCA to protect & enhance my liver function (Source). I do this out of an abundance of caution, as I consume many herbal supplements that may have some degree of hepatotoxicity. I typically take 500mg per day of Nutracost’s TUDCA.
#3 - Astragalus
Astragalus is a traditional Chinese herb that has been shown to have potent anti-aging properties. I take Astragalus to support my kidney health and protect them from damage caused by oxidative stress (Source). Studies have also shown that Astragalus can promote telomere elongation, which can improve cellular health and slow down the aging process. I take 5g of Astragalus Extract from NOW per day.
#4 - Citrus bergamot
Citrus bergamot is one of the best, if not the best, supplements to lower cholesterol (Source). Citrus Bergamot is also a strong antioxidant that can help to reduce oxidative stress in the body. It has also been shown to inhibit PCSK9 expression, a protein that can interfere with the liver's ability to remove LDL cholesterol from the bloodstream. By inhibiting PCSK9, Citrus Bergamot can help to further lower LDL cholesterol levels and reduce the risk of heart disease. I use one serving of U.S. Doctors’ Clinical CitriCholess® as it is the form that has been used in clinical trials.
#5 - Nigella sativa
Nigella Sativa, also known as Black Seed or Black Seed Oil, is a widely used medicinal plant with a long history of use in traditional medicine systems. According to Prophet Muhammed, it’s “the cure for everything except death.” While this is a bit of a stretch, the science seems to agree with him:
A review on therapeutic potential of Nigella sativa: A miracle herb
Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure
An updated literature-based review: phytochemistry, pharmacology and therapeutic promises of Nigella sativa
I take nigella sativa primarily to enhance immune function & reduce systemic inflammation, but it also has a wide range of other therapeutic properties, including antidiabetic, anticancer, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, renal protective, gastro-protective, anti-depressant, anxiolytic, and antioxidant properties. The primary bioactive component of Nigella Sativa is thymoquinone, which is found in the essential oil of the seeds. If you ever start taking nigella sativa or black seed oil, I recommend finding an extract/oil with standardized to at least 3-5% of thymoquinone content. I take 400mg of nigella sativa extract (5% thymoquinone) from Nootropics Depot daily.
#6 - Sodium Butyrate
Butyrate is a short-chain fatty acid that is produced by the gut microbiota and is also found in dietary sources like butter and cheese. I take Sodium Butyrate (as this is the supplemental form used in many studies) primarily for its potent gut-healing properties. It activates the GPR109A receptor which influences intestinal permeability & gastrointestinal inflammation. It also has anti-cancer properties via HDAC inhibition & neuroprotective properties via inducing BDNF & GDNF. I take 2 capsules (equivalent to 1.2g butyric acid) per day from BodyBio.
#7 - Goat Colostrum
Goat colostrum is a superfood that contains a rich array of active immune systems compounds, such as peptides, immunoglobulins (IgG, IgA, and IgM), lactoferrin, cytokines, and more than 20 different antibodies for immune support. Lactoferrin is particularly important when trying to control unbound iron, which is highly inflammatory and contributes to all sorts of issues. That said, I take goat colostrum primarily to bulletproof my digestive system & reduce intestinal permeability (otherwise known as “leaky gut”). I take 1 serving of Mt. Capra’s goat colostrum daily.
By the way, goat colostrum is thought to be more easily digestible than bovine colostrum and absorbed by the body due to its smaller fat globules and looser protein curd structure. This may make it a more suitable option for individuals with lactose intolerance, cow's milk allergies, or sensitive digestive systems.
#8 - Liposomal Glutathione
Liposomal Glutathione is a highly bioavailable form of the "master antioxidant" with approximately 10x the absorption of traditional glutathione supplements. Its potency lies in its ability to combat oxidative stress, neutralize harmful free radicals, & reduce inflammation. In turn, this protects your body & allows your cells to function optimally. The corresponding benefits are almost countless:
enhance detoxification
improve skin aesthetics
protect brain
reduce mental illness
enhance immunity & fight infections
improve cardiovascular health
improve gut health
In other words, it does just about everything. Rho Nutrition has very high-quality liposomal glutathione that I use 1-2 servings of daily. You can use the code ‘NOOTBRO10” to get 10% off.
Testosterone & Aphrodisiac Supplements
#9 - Shilajit
Shilajit is a naturally occurring resin that has been used for thousands of years in indigenous medicine systems for its anti-inflammatory, antioxidant, aphrodisiac, anti-pain, mitochondrial enhancing, and nootropic activities. Its benefits are largely attributed to the high concentration of fulvic & humic acids and dibenzo-α-pyrones, as well as its mineral makeup. I specifically use Shilajit to boost testosterone, libido, & energy. It’s one of the few herbal supplements that you can really “feel” despite it not having a direct action on dopamine or norepinephrine. I take 8 tablets of Based Shilajit dissolved in spring water daily. I don’t recommend taking 8 though; 2-4 does the trick and is less likely to cause any side effects. I mix mine in 1L of spring water bottled. in glass.
Shilajit is a supplement that often is contaminated with heavy metals & mycotoxins, so you have to be careful who you buy from. Based does extensive third-party lab testing to confirm purity, potency, & lack of contaminants for their products. You can use ‘NOOTBRO’ for 10% off.
#10 - Cistanche tubulosa
Cistanche is a herb commonly used in traditional Chinese medicine for its potential health benefits, including positively modulating the gut-brain axis, increasing expression of GDNF for dopaminergic neuronal repair, and improving testosterone levels and fertility by enhancing steroidogenic enzyme expression. I take 200mg of Cistanche tubulosa extract from Nootropics Depot daily.
#11 - Tribulus
Tribulus Terrestris is a herb commonly used for its potential benefits in increasing testosterone levels and enhancing athletic performance. It contains steroidal saponins called protodioscin and dioscin, which have been shown to increase DHT production by increasing the 5-alpha-reductase enzyme. Additionally, it contains beta-carbolines that inhibit MAO enzymes, resulting in greater levels of serotonin, dopamine, and norepinephrine. I take 500mg of Tribulus from Nootropics Depot daily.
Note that Tribulus may raise liver enzymes, but taking TUDCA & NAC will help mitigate this damage. High doses of astragalus extract will help counteract any potential kidney damage from Tribulus or other herbal supplements.
Nootropics
#12 - Notable Focus
Notable Focus is a formulation designed to enhance cognition quickly using underrated herbal ingredients. I won’t be revealing the entire formula here, but it contains two heavy hitters: Sabroxy & Polygala tenuifolia. Both of these have been shown to boost dopamine (& other neuromodulators) significantly in a way that vastly outperforms almost all other supplements, nootropics, & herbs. Both inhibit monoamine reuptake, and Poylgala also inhibits monoamine oxidase, resulting in significantly higher levels of dopamine. I take 1-2 servings per day.