I've tried over 100+ supplements.
Agmatine is one of the ones that blew me away.
It has rapid-onset antidepressant effects like its cousin ketamine (via NMDA antagonism & downstream AMPA signaling)
But unlike ketamine it's:
Cheap
Low risk
Available OTC
No hallucinogenic effects
I used Agmatine extensively in 2020 when I was suffering from depression can attest …